In this presentation, Purilogics by Donaldson introduces the concept of using high-performance membrane chromatography technologies to rapidly purify SC pDNA and mRNA. We will illustrate purifying SC pDNA by capture chromatography using Purexa™ NAEX Plus, a weak anion chromatography membrane, followed by a polishing step using Purexa™ MCP, a hydrophobic interaction chromatography membrane that has superior and consistent capability to separate SC pDNA from open circular pDNA. We will illustrate purifying mRNA using Purexa™ OdT, an affinity capture chromatography membrane targeting the Poly A tails in mRNA.

Listen to company co-founder, Jin Zhou on how Purexa™ NAEX+ and MCP demonstrates fast and efficient purification of super coiled DNA, as well as how Purexa™ OdT shows superior performance in mRNA/IVT Purification. Purilogics products provide solutions and are tailored for high-throughput nucleic acid purification. Listen to this webinar to learn how to increase mRNA purification production with novel membrane chromatography.

This interview features: Jin Zhou, Co-Founder, Business Leader, Purilogics By Donaldson, from BioProcess International 2023.

Purilogics’ Jinxiang Zhou recently co-authored an article alongside Camila Leal-Lopes, Sara D’Angelo, Andre A.R. Teixeira, Andrew R.M Bradbury, Fortunato Ferrara, and M. Frank Erasmus – the Head of Bioinformatics at Specifica, Inc. We are excited to announce that this article has been published in the New Biotechnology Journal: High throughput purification of monoclonal recombinant antibodies using a Protein-A coated membrane plate system.

Gene therapy involves the manipulation of gene expression pathways in cells utilized in the treatment of both genetic and pathological diseases. The delivery of genetic-based material, such as RNA or DNA, to cells modifies their expression patterns.

Recent developments in research have highlighted the potential of non-viral nanoparticles as vectors in gene therapy. Gene therapy typically refers to the use of nucleic acids, such as plasmids and siRNA, to genetically modify patient’s cells.1 Traditionally, viral vectors have been pursued as gene delivery vehicles, but a variety of risks and problems associated with them have limited their large-scale use clinically.

Recent developments have made small-scale antibody expression much easier. Upstream scientists can express tens or hundreds of antibodies in parallel. Analysis of purified samples at early stage will likely improve long-term success rate because there will be a reduction in interference of impurities.

In vitro-transcribed (IVT) mRNA is an alternative genetic material that can be used in the replacement of plasmid DNA in conventional uses…

How can Purilogics help? We offer membrane columns for small-scale antibody purification. Our mini and midi columns can be used with a syringe to purify small volumes of antibody.

Over the past few years, we have seen a steady increase in the demand for plasmid DNA, as the gene and cell therapy industries have experienced rapid growth…

We’re excited to attend the Antibody Engineering & Therapeutics Conference in San Diego, CA from December 13th to 17th! Hosted by the Antibody Society, which is dedicated to the promotion of antibody research and development, this conference showcases the latest antibody technologies and science to accelerate next generation antibodies towards commercial success.

Hydrophobic interaction chromatography (HIC) separates molecules based on differences in their hydrophobicity. It is an important technique in both sample analysis and preparative scale purification…

mRNA impurities need to be removed to achieve high potency and safety throughout the production process. mRNA production begins with plasmid DNA, which then needs to be linearized.

Purilogics offers a wide variety of differentiated products for your purification needs. Here are some highlights on the uniqueness of our membrane chromatography products:..

Purilogics is currently developing a novel and first-in-market high-capacity, -selectivity, and -throughput affinity membrane for the purification of mRNA…

Fast protein liquid chromatography (FPLC) is a common purification technique used widely in various biologics preparation. Often, we complain how slow chromatography columns are, but we have ignored that FPLC itself can cause more trouble than it is worth.

Over the past 18 months, there has been a sharp rise in interest concerning the development of mRNA-based therapies, as highlighted by the FDA’s Emergency Use Authorization and subsequent approval of one of two novel SARS-CoV-2 mRNA vaccines.

A key focus of Purilogics is to emphasize the drastic decrease in processing time when using our membranes for biologics purification…

Imagine a glass holding sugar. After adding water, it is left to sit. Ultimately, the sugar will dissolve after a few hours…